Carlsson P O, Jansson L
Department of Medical Cell Biology, Uppsala University, Sweden.
Pancreas. 1994 May;9(3):361-4. doi: 10.1097/00006676-199405000-00013.
The effects of intravenously administered octreotide (5 or 10 micrograms/kg body weight) on pyloric, duodenal, colonic, pancreatic, and islet blood flow were investigated with a microsphere technique in anesthetized rats. The lower dose of octreotide reduced only pyloric blood flow, while the higher dose caused a reduction also in duodenal and colonic blood flow. Whole pancreatic blood flow was not affected by either of the doses of octreotide, but the blood flow through the islets was decreased by the higher dose. Also, the fraction of whole pancreatic blood flow through the islets was decreased by the higher dose. It is concluded that octreotide mainly affects intestinal blood flow, but not whole pancreatic blood flow in rats. However, octreotide causes a redistribution of the blood flow within the pancreas, which leads to a diminished islet blood perfusion, in conjunction with a decrease in serum insulin concentration.
采用微球技术，在麻醉大鼠中研究了静脉注射奥曲肽（5或10微克/千克体重）对幽门、十二指肠、结肠、胰腺和胰岛血流的影响。较低剂量的奥曲肽仅降低幽门血流，而较高剂量还会导致十二指肠和结肠血流减少。两种剂量的奥曲肽均未影响胰腺整体血流，但较高剂量会使通过胰岛的血流减少。此外，较高剂量还会降低通过胰岛的胰腺整体血流比例。得出的结论是，奥曲肽主要影响大鼠的肠道血流，但不影响胰腺整体血流。然而，奥曲肽会导致胰腺内血流重新分布，这会导致胰岛血流灌注减少，同时血清胰岛素浓度降低。
