Paré W P
V.A. Medical Center, Perry Point, MD 21902.
Physiol Behav. 1994 May;55(5):975-8. doi: 10.1016/0031-9384(94)90090-6.
Unconditioned suppression of feeding due to novelty (hyponeophagia) was studied in Wistar Kyoto (WKY), Lewis, Fischer 344, and Wistar rats. Fasted rats were given access to food either in home cages (controls) or to a single pellet fixed to the middle of a novel open field environment (experimental). The degree of feeding suppression was significantly greater in WKY rats compared to the other three strains. We suggest that this hyponeophagia resembles the reduced feeding frequently associated with behavioral depression, and that this behavior in WKY rats is another demonstration that this strain is very responsive to stressful stimulation and may serve as a useful animal model for depressive behavior.
在Wistar Kyoto（WKY）大鼠、Lewis大鼠、Fischer 344大鼠和Wistar大鼠中研究了由于新奇性导致的无条件摄食抑制（低新食物摄取）。将禁食的大鼠置于其笼舍中获取食物（对照组），或置于固定在新的开阔场地环境中央的单个食丸处获取食物（实验组）。与其他三个品系相比，WKY大鼠的摄食抑制程度明显更高。我们认为这种低新食物摄取类似于经常与行为性抑郁相关的摄食减少，并且WKY大鼠的这种行为是该品系对压力刺激非常敏感的又一证明，可能是抑郁行为的有用动物模型。
