Paré W P
Veterans Administration Medical Center, Perry Point, MD 21902.
Physiol Behav. 1993 Nov;54(5):845-52. doi: 10.1016/0031-9384(93)90291-m.
In Experiment 1, Wistar-Kyoto (WKY), Wistar, and Fischer-344 (F-344) rats were tested on two passive-avoidance tasks: a platform step-down task and a one-way avoidance task. Wistars had shorter response latency scores in the step-down task, whereas F-344 rats had shorter scores in the one-way task. A subsequent ulcerogenic water-restraint stress produced significantly fewer ulcers in Wistar rats as compared to WKY and F-344 rats. In Experiment 2, rearings, grooming, ambulation, defecation, and response ambivalence behaviors were recorded in the one-way avoidance task in addition to response latency. WKY rats defecated more and produced lower scores on the three activity measures as compared to Wistar and F-344 rats. Response latency and ambivalence scores were higher for WKY rats. The subsequent ulcerogenic procedure also produced more ulcers in WKY rats. These data verify the ulcer susceptibility of WKY rats and underscore the assertion that their predominant stress coping behaviors are immobility and freezing. High ambivalence scores in WKY rats suggest behavioral inhibition, which is readily elicited by stressors. These behaviors resemble depressive behavior and suggest that WKY rat may be a useful animal model of depression.
在实验1中，对Wistar - Kyoto（WKY）大鼠、Wistar大鼠和Fischer - 344（F - 344）大鼠进行了两项被动回避任务测试：平台跳下任务和单向回避任务。Wistar大鼠在跳下任务中的反应潜伏期得分较短，而F - 344大鼠在单向任务中的得分较短。随后的致溃疡水限制应激在Wistar大鼠中产生的溃疡明显少于WKY大鼠和F - 344大鼠。在实验2中，除了反应潜伏期外，还记录了单向回避任务中的竖毛、理毛、走动、排便和反应矛盾行为。与Wistar大鼠和F - 344大鼠相比，WKY大鼠排便更多，在三项活动指标上得分更低。WKY大鼠的反应潜伏期和矛盾得分更高。随后的致溃疡程序在WKY大鼠中也产生了更多溃疡。这些数据证实了WKY大鼠对溃疡的易感性，并强调了它们主要的应激应对行为是不动和僵住的观点。WKY大鼠较高的矛盾得分表明其行为受到抑制，这很容易被应激源诱发。这些行为类似于抑郁行为，表明WKY大鼠可能是一种有用的抑郁症动物模型。
