Mabin D, Fourquet I, Richard P, Esnault S, Islam M S, Bourbigot B
Service d'Explorations Fonctionnelles Neurologiques, Centre Hospitalier Régional et Universitaire de Brest.
Rev Neurol (Paris). 1993;149(10):576-8.
We report a case of leucoencephalopathy with tremor and generalized motor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient. There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1 260 ng/ml; therapeutic range: 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present. All neurological symptoms were reversible after Cy A level was lowered. Three months later, a blood Cy A level at 217 ng/ml due to nicardipine co-administration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.
我们报告了1例肾移植受者在使用环孢素A（Cy A）几天后出现伴有震颤和全身性运动性癫痫发作的白质脑病病例。急性神经症状与Cy A血药浓度急剧升高（1260 ng/ml；治疗范围：120 - 275 ng/ml）之间存在关联。CT扫描显示白质低密度影，脑电图显示严重的慢波异常。在Cy A血药浓度降低后，所有神经症状均可逆。3个月后，因联合使用尼卡地平导致血Cy A浓度为217 ng/ml，患者出现严重震颤，将血Cy A浓度降至126 ng/ml后症状缓解。
