Shimizu C, Kimura S, Yoshida Y, Nezu A, Saitoh K, Osaka H, Aihara Y, Nagasaka Y
Department of Paediatrics, Urafune Hospital of Yokohama City University School of Medicine, Kanagawa, Japan.
Pediatr Nephrol. 1994 Aug;8(4):483-5. doi: 10.1007/BF00856540.
A 13-year-old girl with nephrotic syndrome (NS) developed acute leucoencephalopathy during combination therapy with cyclosporin A (CyA) and prednisolone (PSL). The patient had a generalized motor seizure followed by coma at 19 days after CyA administration. Magnetic resonance scanning performed on the 1st hospital day revealed white matter lesions in the subcortices of the parietal and occipital lobes, brain stem and cerebellum. These lesions had completely resolved on the 10th hospital day. This episode might be caused by CyA because the clinical course and laboratory data revealed neither inflammation nor other causative factors. To our knowledge, this is the first report of acute leucoencephalopathy during combination therapy with CyA and PSL in a patient with NS.
一名患有肾病综合征（NS）的13岁女孩在接受环孢素A（CyA）和泼尼松龙（PSL）联合治疗期间发生了急性白质脑病。该患者在使用CyA后第19天出现全身性惊厥，随后昏迷。入院第1天进行的磁共振扫描显示顶叶和枕叶皮质下、脑干和小脑有白质病变。这些病变在入院第10天时已完全消退。这一发作可能是由CyA引起的，因为临床病程和实验室数据均未显示有炎症或其他致病因素。据我们所知，这是NS患者在CyA和PSL联合治疗期间发生急性白质脑病的首例报告。
