Frey B M, Morant R, Senn H J, Fisch T, Schmid U
Abteilung für Onkologie-Hämatologie, Medizinische Klinik C, Kantonsspital St. Gallen.
Schweiz Med Wochenschr. 1994 Jun 11;124(23):1010-6.
Based on the observation of 5 patients with simultaneous breast cancer and malignant lymphoma, we discuss the phenomenon of synchronicity of two different tumors in the same individual. Synchronicity of malignancy is rare and could point to a genetic predisposition (family history) or common environmental influence in generating cancer. In elderly patients, the appearance of multiple tumors may coincide by chance. In the case of synchronous or metachronous tumors it is essential to examine the new tumor manifestation by biopsy. In view of the therapeutic and prognostic implications, the second tumor should not be confused with a progression of the known primary malignancy.
基于对5例同时患有乳腺癌和恶性淋巴瘤患者的观察，我们探讨了同一患者体内两种不同肿瘤的同时性现象。恶性肿瘤的同时性很罕见，可能提示存在遗传易感性（家族史）或共同的环境因素影响癌症的发生。在老年患者中，多种肿瘤的出现可能是偶然巧合。对于同时性或异时性肿瘤，通过活检检查新的肿瘤表现至关重要。鉴于治疗和预后的影响，不应将第二种肿瘤与已知原发性恶性肿瘤的进展相混淆。
