Galván-Arzate S, Ríos C
Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugia Manuel Velasco Suárez, Secretaria de Salud Insurgentes, México, D.F., Mexico.
Toxicology. 1994 May 31;90(1-2):63-9. doi: 10.1016/0300-483x(94)90205-4.
The concentration of thallium in body organs and brain regions was studied in rats as a function of the animals age from newborn to 20-days old. Thallium was analyzed at different times after a single sublethal i.p. injection of the metal (16 mg/kg). The results indicate that the brain is less permeable to thallium in the older animals, suggesting that reduced thallium transport into the brain is related to the establishment of the blood-brain barrier in the rats. Differences between weanling and newborn rats were also found in regard to regional distribution of thallium in the brain as the older animals showed a region-dependent distribution while newborn rats presented an homogeneous content of thallium among all regions.
研究了新生至20日龄大鼠体内各器官和脑区铊的浓度与动物年龄的关系。在单次腹腔注射亚致死剂量的金属铊（16毫克/千克）后的不同时间对铊进行了分析。结果表明，在年龄较大的动物中，大脑对铊的通透性较低，这表明铊向大脑的转运减少与大鼠血脑屏障的建立有关。在断奶大鼠和新生大鼠之间还发现了大脑中铊的区域分布差异，因为年龄较大的动物呈现出区域依赖性分布，而新生大鼠在所有区域的铊含量均一。
