Merk H F
Universitäts-Hautklinik Köln, Deutschland.
Wien Med Wochenschr. 1994;144(4):88-92.
Mast cells and basophils play a central role in the pathophysiology of immediate type allergic reactions. After binding of at least 2 IgE-antibodies with the antigen, the mediators of inflammation of these cells are released. Major progress in our understanding of this mechanism changed our knowledge about the pharmacologic properties of histamine antagonists. It could be demonstrated that some of them possess antiallergic properties, that means that they inhibit the release of mediators of inflammation of mast cells and basophils.
肥大细胞和嗜碱性粒细胞在速发型过敏反应的病理生理学中起核心作用。至少2种IgE抗体与抗原结合后，这些细胞的炎症介质被释放。我们对这一机制的理解取得的重大进展改变了我们对组胺拮抗剂药理特性的认识。可以证明，其中一些具有抗过敏特性，也就是说它们能抑制肥大细胞和嗜碱性粒细胞炎症介质的释放。
