Bettin S, Halle H, Wenzkowski B M, Volk H D, Jahn S
Frauenklinik der Charité, Universitätsklinikum Berlin.
Zentralbl Gynakol. 1994;116(5):260-2.
Immunological investigations were carried in women with normal pregnancy and patients with preeclampsia. Regarding the lymphocyte subpopulation distribution an elevated number of T lymphocytes, especially of CD-4 carrying helper-inducer T cells, was registered resulting in an altered CD4/CD8 ratio. The T lymphocytes in patients with pre-eclampsia seem to be activated in vivo, shown by an elevated expression of the CD25 (IL-2 receptor) marker. Their responsibility to phytohemagglutinin (PHA) in vitro was found to be depressed. Furthermore, a pre-stimulation of macrophages in vivo was registered (expression of the transferrin receptor). In comparison to the control group the serum levels of IgG and IgA were seen to be low in patients with pre-eclampsia.
对正常妊娠女性和先兆子痫患者进行了免疫学研究。关于淋巴细胞亚群分布，发现T淋巴细胞数量增加，尤其是携带辅助诱导型T细胞的CD-4细胞，导致CD4/CD8比值改变。先兆子痫患者的T淋巴细胞似乎在体内被激活，这表现为CD25（白细胞介素-2受体）标志物表达升高。发现它们在体外对植物血凝素（PHA）的反应性降低。此外，还记录到体内巨噬细胞的预刺激（转铁蛋白受体的表达）。与对照组相比，先兆子痫患者的血清IgG和IgA水平较低。
