大鼠脑缺血后低灌注的严重程度随脑缺血持续时间的增加而加重。
The severity of postischemic hypoperfusion increases with duration of cerebral ischemia in rats.
作者信息
Karlsson B R, Grögaard B, Gerdin B, Steen P A
机构信息
Department of Anesthesiology, Ullevål University Hospital, Oslo, Norway.
出版信息
Acta Anaesthesiol Scand. 1994 Apr;38(3):248-53. doi: 10.1111/j.1399-6576.1994.tb03883.x.
Regional cerebral blood flow was studied after a period of hypotensive bilateral carotid occlusion in rats. As other studies have found, we confirm that 15 min of ischemia caused an initial brief hyperemic episode followed by severe hypoperfusion in all areas. With varying duration of ischemia from 5 to 10, 15 and 20 min, the median cerebral blood flow 60 min postischemia was 79%, 46%, 48% and 34% of control, respectively. Thus the degree of postischemic hypoperfusion increased significantly with the duration of ischemia.
在大鼠经历一段双侧颈动脉低血压性闭塞后，对其局部脑血流量进行了研究。正如其他研究发现的那样，我们证实，15分钟的缺血会引发最初短暂的充血期，随后所有区域出现严重的灌注不足。随着缺血时间从5分钟、10分钟、15分钟到20分钟变化，缺血后60分钟时的脑血流量中位数分别为对照组的79%、46%、48%和34%。因此，缺血后灌注不足的程度随着缺血时间的延长而显著增加。
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