Bodnár E, Antal L, Kata M
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszertechnológiai Intézet, Szeged.
Acta Pharm Hung. 1994 Jan;64(1):31-4.
A study was made of how different cyclodextrin (CD) derivatives, such as alpha-CD, beta-CD, gamma-CD, dimethyl-beta-CD and random-methyl-beta-CD, influence the diffusion of paracetamol. For interpretation of the phenomena, dissolution rate investigations, measurements of surface tension and determinations of partition coefficients were also performed. It was established that paracetamol has a low diffusion ability. It was also found that the different CD derivatives exert their influence in diverse ways, which depend on, among others, the cyclodextrin ratio and the mode of preparation of the product. These complementary examinations are useful for an explanation of the phenomena.
研究了不同的环糊精（CD）衍生物，如α-环糊精、β-环糊精、γ-环糊精、二甲基-β-环糊精和随机甲基-β-环糊精，对扑热息痛扩散的影响。为了解释这些现象，还进行了溶解速率研究、表面张力测量和分配系数测定。结果表明，扑热息痛的扩散能力较低。还发现，不同的环糊精衍生物以不同的方式发挥作用，这尤其取决于环糊精比例和产品的制备方式。这些补充性研究有助于解释这些现象。
