Kuwahara M, Takagi N, Nishitani M, Matsushita K, Nakamura K, Fujisaki N
Department of Urology, Fujisaki Hospital.
Hinyokika Kiyo. 1994 May;40(5):439-42.
In these past three years, we treated 5 patients who attempted suicide by taking paraquat, a herbicide that had been kept at home, by direct hemoperfusion (DHP) alone or in combination with double filtration plasmapheresis (DFPP) in addition to conservative therapy. DHP alone was performed on 3 patients, 2 of whom recovered. The other 1 patient treated by DHP alone and 2 treated by the combination therapy died. These patients showed a plasma paraquat concentration exceeding the survival curve presented by Proudfoot. In such patients, appropriate combinations among hemodialysis, hemofiltration, DHP, and DFPP may be safer and more effective than each therapy alone.
在过去三年里，我们治疗了5例试图通过服用百草枯自杀的患者，百草枯是一种曾存放在家中的除草剂，除了保守治疗外，我们单独采用直接血液灌流（DHP）或联合双重过滤血浆置换（DFPP）对他们进行治疗。3例患者单独接受了DHP治疗，其中2例康复。另外，1例单独接受DHP治疗的患者和2例接受联合治疗的患者死亡。这些患者的血浆百草枯浓度超过了Proudfoot给出的生存曲线。对于此类患者，血液透析、血液滤过、DHP和DFPP之间的适当联合可能比单一疗法更安全、更有效。
