Davis J M
Arch Gen Psychiatry. 1976 Jul;33(7):858-61. doi: 10.1001/archpsyc.1976.01770070088010.
It is clinically useful to have a table listing the equivalent doses of the various neuroleptics to a standard, such as chlorpromazine. This article derives such data by reviewing double-blind controlled studies that used a flexible dosage schedule of neuroleptics in treating schizophrenic patients. Each neuroleptic is then converted to 100-mg chlorpromazine equivalents. This empirically derived dosage comparability table is compared with a similar table derived from the opinions of experts. Since these comparable doses produce equivalent amounts of antipsychotic activity, the cost to provide such medication was then calculated, and a table comparing the costs of the different neuroleptics was constructed. In absolute amounts, the cost differences between drugs are small. However, for any drug, large savings accrue when the largest possible capsule or tablet to achieve the desired dose is prescribed.
拥有一张列出各种抗精神病药物与标准药物（如氯丙嗪）等效剂量的表格在临床上是很有用的。本文通过回顾双盲对照研究得出此类数据，这些研究在治疗精神分裂症患者时使用了灵活的抗精神病药物剂量方案。然后将每种抗精神病药物换算为100毫克氯丙嗪等效剂量。将这个根据经验得出的剂量可比性表格与从专家意见中得出的类似表格进行比较。由于这些可比剂量产生等量的抗精神病活性，随后计算了提供此类药物的成本，并构建了一个比较不同抗精神病药物成本的表格。从绝对金额来看，药物之间的成本差异很小。然而，对于任何一种药物，当开出处方以使用能达到所需剂量的最大胶囊或片剂时，会节省大量费用。
