外周蛙皮素部分通过大鼠的迷走神经通路降低胃迷走神经传出活动。
Peripheral bombesin decreases gastric vagal efferent activity in part through vagal pathways in rats.
作者信息
Yoshida-Yoneda E, Taché Y, Kosoyan H P, Wei J Y
机构信息
Veterans Affairs Wadsworth Medical Center, Department of Medicine, Los Angeles, California.
出版信息
Am J Physiol. 1994 Jun;266(6 Pt 2):R1868-75. doi: 10.1152/ajpregu.1994.266.6.R1868.
The influence of intravenous (iv) bombesin on multiunit activities recorded from the ventral gastric branch of the vagus was investigated in urethan-anesthetized rats. Consecutive injections of bombesin (0.062, 0.62, 6.2, 62, and 620 pmol iv) decreased dose dependently gastric vagal efferent discharges to 79.8 +/- 4.9, 68.3 +/- 10.2, 47.0 +/- 6.7, 41.6 +/- 4.7, and 36.5 +/- 8.9%, respectively, from preinjection levels. Saline injection had no effect. Bombesin (62 pmol iv) reduced cervical vagal efferent discharges to 25 +/- 6% before and 67 +/- 5% after bilateral cervical vagotomy distal to the recording site. Bombesin (62 and 620 pmol iv) increased gastric vagal afferent discharges by 45 and 93%, respectively. These data show that systemic injection of bombesin potently decreases gastric and cervical vagal efferent activity in part through vagal-dependent mechanisms that may involve the increase in gastric vagal afferent activity.
在乌拉坦麻醉的大鼠中，研究了静脉注射蛙皮素对迷走神经腹侧胃支记录的多单位活动的影响。连续静脉注射蛙皮素（0.062、0.62、6.2、62和620 pmol）后，胃迷走神经传出放电剂量依赖性降低，分别降至注射前水平的79.8±4.9%、68.3±10.2%、47.0±6.7%、41.6±4.7%和36.5±8.9%。注射生理盐水无影响。静脉注射蛙皮素（62 pmol）使双侧颈迷走神经在记录部位远端切断前的颈迷走神经传出放电降至25±6%，切断后降至67±5%。静脉注射蛙皮素（62和620 pmol）分别使胃迷走神经传入放电增加45%和93%。这些数据表明，全身注射蛙皮素可部分通过迷走神经依赖性机制有效降低胃和颈迷走神经传出活动，该机制可能涉及胃迷走神经传入活动的增加。
Zotero 插件