Benington J H, Heller H C
Department of Biological Sciences, Stanford University, California 94305.
Am J Physiol. 1994 Jun;266(6 Pt 2):R1992-2000. doi: 10.1152/ajpregu.1994.266.6.R1992.
Sleep structure in the rat was characterized during uninterrupted full-day recordings using an analytic procedure that identifies rapid eye movement (REM) sleep episodes based on REM-sleep-onset electroencephalograph phenomena, hence independently of REM-sleep duration. The data were used to determine whether REM-sleep timing is controlled homeostatically or by an oscillatory mechanism. The findings and conclusions are that 1) non-REM (NREM) sleep episode duration is positively correlated with prior REM-sleep episode duration, suggesting that REM-sleep expression is permissive of NREM sleep; 2) mean NREM-sleep episode duration decreases after repeated brief REM-sleep episodes (< 30 s), also suggesting that discharge of REM-sleep propensity is essential for NREM-sleep expression; 3) REM-sleep episode duration is independent of prior sleep history, suggesting that REM-sleep maintenance is controlled by factors other than accumulated REM-sleep propensity; 4) brief REM-sleep episodes occur progressively more frequently over the course of the NREM-sleep interval between sustained REM-sleep episodes (> 30 s), suggesting that REM-sleep propensity increases progressively within episodes of NREM sleep; and 5) the diurnal cycle of REM-sleep expression primarily reflects modulation in the efficiency of REM-sleep maintenance. These findings support the hypothesis that REM-sleep timing is controlled by accumulation of REM-sleep propensity during NREM sleep.
在大鼠的睡眠结构研究中，通过一种分析程序在全天不间断记录过程中对其进行了表征。该程序基于快速眼动（REM）睡眠起始脑电图现象识别REM睡眠阶段，因此与REM睡眠持续时间无关。这些数据用于确定REM睡眠时间是由稳态控制还是由振荡机制控制。研究结果和结论如下：1）非快速眼动（NREM）睡眠阶段持续时间与先前的REM睡眠阶段持续时间呈正相关，这表明REM睡眠的出现有利于NREM睡眠；2）在多次短暂的REM睡眠阶段（<30秒）后，平均NREM睡眠阶段持续时间缩短，这也表明REM睡眠倾向的释放对于NREM睡眠的出现至关重要；3）REM睡眠阶段持续时间与先前的睡眠历史无关，这表明REM睡眠的维持受累积的REM睡眠倾向以外的因素控制；4）在持续的REM睡眠阶段（>30秒）之间的NREM睡眠间隔过程中，短暂的REM睡眠阶段出现得越来越频繁，这表明在NREM睡眠阶段REM睡眠倾向逐渐增加；5）REM睡眠出现的昼夜周期主要反映了REM睡眠维持效率的调节。这些发现支持了以下假设：REM睡眠时间是由NREM睡眠期间REM睡眠倾向的积累所控制的。
