Sioshansi P
Spire Corporation, Bedford, Massachusetts 01730-2396.
Artif Organs. 1994 Apr;18(4):266-71. doi: 10.1111/j.1525-1594.1994.tb02193.x.
Infection, thrombosis, and stenosis are among the most common complications of blood-contacting catheters and are caused by surface properties of the substrate materials. Ion beam-based processes such as ion implantation and ion beam-assisted deposition affect only the outer micron of the treated material surface; there is little effect on bulk properties. These processes were therefore used on common catheter materials, and their biological properties were evaluated. Ion implantation of materials such as silicone rubber resulted in a less tacky, more wettable surface that demonstrated thrombus-resistance in both in vivo and preliminary clinical studies. Ion beam-assisted deposition was used to deposit silver-based coatings, which demonstrated antimicrobial activity in in vitro and clinical studies. Biocompatibility of these processed catheter materials was also demonstrated using simple laboratory studies. These processes, therefore, can be readily applied to blood-contacting catheters to make them thrombus- and infection-resistant.
感染、血栓形成和血管狭窄是接触血液的导管最常见的并发症，它们是由基底材料的表面特性引起的。基于离子束的工艺，如离子注入和离子束辅助沉积，仅影响被处理材料表面的外层微米；对整体性能几乎没有影响。因此，这些工艺被应用于常见的导管材料，并对其生物学特性进行了评估。对诸如硅橡胶等材料进行离子注入后，表面粘性降低、润湿性增强，在体内和初步临床研究中均显示出抗血栓性。采用离子束辅助沉积来沉积银基涂层，在体外和临床研究中均显示出抗菌活性。通过简单的实验室研究也证明了这些经过处理的导管材料的生物相容性。因此，这些工艺可以很容易地应用于接触血液的导管，使其具有抗血栓和抗感染能力。
