Wilks A F, Harpur A G
Growth Regulation Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.
Bioessays. 1994 May;16(5):313-20. doi: 10.1002/bies.950160505.
Cytokine receptors fall into two basic classes: those with their own intrinsic protein tyrosine kinase (PTK) domain, and those lacking a PTK domain. Nonetheless, PTK activity plays a fundamental role in the signal transduction processes lying downstream of both classes of receptor. It now seems likely that many of those cytokine receptors that lack their own PTK domain use members of the JAK family of PTKs to propagate their intracellular signals. Moreover, the involvement of the JAK kinases in a newly defined pathway which links membrane receptors directly to the activation of nuclear genes, via latent cytoplasmic transcription factors known as STATs (for Signal Transducers and Activators of Transcription), appears to be a theme common to cytokine receptors of both classes.
一类具有自身内在的蛋白酪氨酸激酶（PTK）结构域，另一类则缺乏PTK结构域。尽管如此，PTK活性在这两类受体下游的信号转导过程中都起着至关重要的作用。现在看来，许多缺乏自身PTK结构域的细胞因子受体利用PTK的JAK家族成员来传递其细胞内信号。此外，JAK激酶参与了一条新定义的途径，该途径通过称为STATs（信号转导子和转录激活子）的潜在细胞质转录因子，将膜受体直接与核基因的激活联系起来，这似乎是这两类细胞因子受体共有的一个特点。
