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Synthesis and diuretic activity of (E)-2-methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxald ehyde dimethylaminoacetohydrazone.

作者信息

Andreani A, Rambaldi M, Locatelli A, Malandrino S, Pifferi G

机构信息

Università di Bologna, Dipartimento di Scienze Farmaceutiche, Italy.

出版信息

Arzneimittelforschung. 1994 May;44(5):618-9.

PMID:8024634
Abstract

(E)-2-Methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxalde hyde dimethylaminoacetohydrazone was synthesized and its configuration determined. The diuretic activity of this compound, evaluated in rats in a dosage range of 2.5, 10 and 40 mg/kg, was higher than that of the reference compounds hydrochlorothiazide and furosemide.

摘要

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