Arora R C, Meltzer H Y
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000.
Neuropsychopharmacology. 1994 Apr;10(2):109-14. doi: 10.1038/npp.1994.12.
The effect of clozapine and typical neuroleptic drug treatment on platelet serotonin2 (5-HT2) binding kinetic constants (Kd, Bmax) was studied in schizophrenic patients. Both treatments increased Bmax by a comparable amount, indicating increased numbers of 5-HT2 sites, although not all typical neuroleptic drugs were effective in this regard. Clozapine, but not typical neuroleptic drugs, increased Kd, indicating a lower affinity of the 5-HT2 sites for 5-HT. In a multiple regression model, low Bmax at baseline predicted poor outcome on Brief Psychiatric Rating Scale measures in the clozapine-treated patients but not the neuroleptic-treated patients.
在精神分裂症患者中研究了氯氮平和典型抗精神病药物治疗对血小板5-羟色胺2（5-HT2）结合动力学常数（Kd，Bmax）的影响。两种治疗均使Bmax增加了相当的量，表明5-HT2位点数量增加，尽管并非所有典型抗精神病药物在这方面都有效。氯氮平而非典型抗精神病药物使Kd增加，表明5-HT2位点对5-羟色胺（5-HT）的亲和力较低。在多元回归模型中，基线时低Bmax预测氯氮平治疗患者在简明精神病评定量表测量中的预后较差，但对使用抗精神病药物治疗的患者则不然。
