Hendrickse W A, Roffwarg H P, Grannemann B D, Orsulak P J, Armitage R, Cain J W, Battaglia J, Debus J R, Rush A J
Mental Health Clinical Research Center, University of Texas Southwestern Medical Center, Dallas.
Neuropsychopharmacology. 1994 Apr;10(2):85-91. doi: 10.1038/npp.1994.10.
The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.
通过对比9名抑郁症门诊患者（8名重度抑郁症患者；1名双相II型障碍抑郁期患者）治疗前及服用氟西汀（FLU）期间的多导睡眠图（PSG），研究了氟西汀及其活性代谢物去甲氟西汀（NFLU）对PSG的影响。PSG变化与每日剂量、累积剂量、单次血清浓度以及FLU和NFLU的血清浓度曲线下总面积（AUC）相关。氟西汀明显增加了1期睡眠时间和快速眼动（REM）潜伏期，同时降低了REM百分比和REM密度。除了少数例外情况，与PSG评估时所测的FLU和NFLU单样本浓度相比，FLU的累积剂量以及FLU和NFLU的AUC能更好地预测PSG中清醒和活动时间的变化。
