Coughlin S R
Cardiovascular Research Institute, University of California, San Francisco 94143-0524.
Curr Opin Cell Biol. 1994 Apr;6(2):191-7. doi: 10.1016/0955-0674(94)90135-x.
The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.
与G蛋白偶联的七跨膜结构域受体的已知种类已在几个有趣的方向上得到扩展。功能丧失和激活突变均已被发现是多种疾病的根源。无疑还会发现更多。触发G蛋白偶联受体的配体的多样性持续增加，与之相伴的是已知的配体检测策略的多样性。这些以及其他进展预示着该领域将持续令人兴奋。
