G蛋白偶联受体：模型、诱变与药物设计 - Suppr

G-Protein coupled receptors: models, mutagenesis, and drug design.

作者信息

Bikker J A, Trumpp-Kallmeyer S, Humblet C

机构信息

Parke-Davis Neuroscience Research Centre, Forvie Site, Robinson Way, Cambridge, United Kingdom CB2 2QB, and Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.

出版信息

J Med Chem. 1998 Jul 30;41(16):2911-27. doi: 10.1021/jm970767a.

DOI:10.1021/jm970767a

PMID:9685229

Abstract

摘要

相似文献

G-Protein coupled receptors: models, mutagenesis, and drug design.G蛋白偶联受体：模型、诱变与药物设计

J Med Chem. 1998 Jul 30;41(16):2911-27. doi: 10.1021/jm970767a.

Dissecting G-protein-coupled receptors: structure, function, and ligand interaction.剖析G蛋白偶联受体：结构、功能及配体相互作用

Chembiochem. 2002 Oct 4;3(10):915-9. doi: 10.1002/1439-7633(20021004)3:10<915::AID-CBIC915>3.0.CO;2-L.

Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein.序列分析揭示了G蛋白偶联受体如何将信号传导至G蛋白。

Proteins. 2003 Sep 1;52(4):553-60. doi: 10.1002/prot.10489.

Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors.基于结构的G蛋白偶联受体结合位点、天然配体及潜在抑制剂的鉴定

Proteins. 2003 May 15;51(3):423-33. doi: 10.1002/prot.10362.

Crystal structure of rhodopsin: a G-protein-coupled receptor.视紫红质的晶体结构：一种G蛋白偶联受体。

Chembiochem. 2002 Oct 4;3(10):963-7. doi: 10.1002/1439-7633(20021004)3:10<963::AID-CBIC963>3.0.CO;2-9.

[Recent advance in studies of G protein-coupled receptors].[G蛋白偶联受体研究的最新进展]

Tanpakushitsu Kakusan Koso. 2001 Aug;46(11 Suppl):1764-71.

Molecular tinkering of G protein-coupled receptors: an evolutionary success.G蛋白偶联受体的分子微调：一项进化上的成功。

EMBO J. 1999 Apr 1;18(7):1723-9. doi: 10.1093/emboj/18.7.1723.

Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.基于视紫红质结构测定对G蛋白偶联受体信号转导的研究

Acta Biochim Pol. 2001;48(4):1203-7.

[Atomic structure of bovine rhodopsin, a seven transmembrane receptor: toward the elucidation of GPCR's molecular mechanism].[牛视紫红质（一种七跨膜受体）的原子结构：迈向GPCR分子机制的阐明]

Tanpakushitsu Kakusan Koso. 2001 May;46(6):687-97.

[Structure-function relationship in G protein-coupled receptors deduced from crystal structure of rhodopsin].从视紫红质晶体结构推导G蛋白偶联受体的结构-功能关系

Tanpakushitsu Kakusan Koso. 2002 Jun;47(8 Suppl):1123-30.

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The beta-D-glucose scaffold as a beta-turn mimetic.β-D-葡萄糖支架作为β-转角模拟物。

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Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor.严重急性呼吸综合征冠状病毒刺突蛋白的270至510位氨基酸是与受体相互作用所必需的。

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G-Protein coupled receptors: models, mutagenesis, and drug design.

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