Sternweis P C
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-9041.
Curr Opin Cell Biol. 1994 Apr;6(2):198-203. doi: 10.1016/0955-0674(94)90136-8.
Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have emerged in the past year. Recent experiments highlight the versatility of beta gamma-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.
许多感知环境的受体通过刺激异源三聚体G蛋白及其产生的后果来影响细胞内调节。虽然最初人们认为G蛋白的α亚基是下游调节的途径，但在过去一年中，βγ亚基也发挥了非常积极的作用。最近的实验突出了βγ亚基在这些调节途径中的多功能性，但也强调了一些仍然存在的基本问题。
