Brownsill R, Combal J P, Taylor A, Bertrand M, Luijten W, Walther B
Servier Research and Development Ltd., Slough, UK.
Rapid Commun Mass Spectrom. 1994 May;8(5):361-5. doi: 10.1002/rcm.1290080504.
The metabolism of S12813, (3-(2-[4-phenyl piperazin-1-yl] ethyl)-2-oxo-2,3-dihydro oxazolo [4,5-b] pyridine chlorohydrate), in rat liver slice incubates was examined by high performance liquid chromatography combined with mass spectrometry. Electrospray ionization was used together with tandem mass spectrometric techniques of analysis (MS/MS). Polar phase I and phase II metabolites were identified as C-oxidation products, which were then conjugated to form either sulphate or glucuronide metabolites. On the basis of the identifications made, a metabolic pathway of S12813 in rat liver slices has been proposed.
通过高效液相色谱与质谱联用技术，对大鼠肝切片孵育物中S12813（3-(2-[4-苯基哌嗪-1-基]乙基)-2-氧代-2,3-二氢恶唑并[4,5-b]吡啶盐酸盐）的代谢情况进行了研究。采用电喷雾电离结合串联质谱分析技术（MS/MS）。极性的I相和II相代谢产物被鉴定为C-氧化产物，这些产物随后会结合形成硫酸盐或葡萄糖醛酸酯代谢产物。基于这些鉴定结果，提出了S12813在大鼠肝切片中的代谢途径。
