Hensrud D D, Heimburger D C
Department of Nutrition Sciences and Medicine, University of Alabama at Birmingham.
Nutrition. 1994 Mar-Apr;10(2):170-5.
Oxidative modification of low-density lipoprotein (LDL) cholesterol may contribute to atherosclerosis by several mechanisms demonstrated in vitro. Antioxidants have been shown to inhibit this process in vitro, and there is evidence from animal studies that they protect against atherosclerosis in vivo. The results of human studies examining the association between antioxidants and cardiovascular disease (coronary heart disease, hypertensive heart disease, and stroke) have been equivocal, although evidence is accumulating that suggests a beneficial effect. Recently, monounsaturated fatty acids incorporated into LDL have been shown to be resistant to oxidation in vitro, compared to polyunsaturated fatty acids. Results from short-term clinical studies are consistent with this finding, as are some epidemiologic data, which suggest that diets containing monounsaturated fatty acids are associated with decreased mortality from cardiovascular disease. The overall roles of antioxidants and particular fatty acids in preventing atherosclerosis require further elucidation.
低密度脂蛋白（LDL）胆固醇的氧化修饰可能通过体外实验证实的多种机制促成动脉粥样硬化。抗氧化剂已被证明在体外可抑制这一过程，并且动物研究中有证据表明它们在体内可预防动脉粥样硬化。尽管越来越多的证据显示有益作用，但关于抗氧化剂与心血管疾病（冠心病、高血压性心脏病和中风）之间关联的人体研究结果并不明确。最近，与多不饱和脂肪酸相比，掺入LDL的单不饱和脂肪酸在体外已被证明对氧化具有抗性。短期临床研究结果与这一发现一致，一些流行病学数据也是如此，这些数据表明含有单不饱和脂肪酸的饮食与心血管疾病死亡率降低相关。抗氧化剂和特定脂肪酸在预防动脉粥样硬化中的总体作用需要进一步阐明。
