Thalidomide may be a mutagen.
作者信息
McBride W G
出版信息
BMJ. 1994 Jun 18;308(6944):1635-6. doi: 10.1136/bmj.308.6944.1635b.
Abstract
摘要
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Thalidomide may be a mutagen.沙利度胺可能是一种诱变剂。
BMJ. 1994 Jun 18;308(6944):1635-6. doi: 10.1136/bmj.308.6944.1635b.
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Thalidomide may not be a mutagen.沙利度胺可能不是一种诱变剂。
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Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.20号染色体上SALL4基因座的突变会导致一系列临床上重叠的表型，包括冲弘综合征、心手综合征、肢-肾-眼综合征，以及之前报道的代表沙利度胺胚胎病的患者。
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Thalidomide is not a human mutagen.沙利度胺不是人类诱变剂。
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Does thalidomide cause second generation birth defects?沙利度胺会导致第二代出生缺陷吗？
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Thalidomide may be a mutagen.沙利度胺可能是一种诱变剂。
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Amniotic band sequence in child of thalidomide victim.沙利度胺受害者子代中的羊膜带序列。
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本文引用的文献
1
Another, late thalidomide abnormality.另一种，即后期沙利度胺异常。
Lancet. 1981 Aug 15;2(8242):368. doi: 10.1016/s0140-6736(81)90689-9.
2
Thalidomide induced alteration in secondary structure of rat embryonic DNA in vivo.沙利度胺在体内诱导大鼠胚胎DNA二级结构发生改变。
Teratog Carcinog Mutagen. 1990;10(4):281-94. doi: 10.1002/tcm.1770100402.
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