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经筛窦视神经减压术。

Trans-ethmoidal optic nerve decompression.

作者信息

Tandon D A, Thakar A, Mahapatra A K, Ghosh P

机构信息

Department of Otorhinolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi.

出版信息

Clin Otolaryngol Allied Sci. 1994 Apr;19(2):98-104. doi: 10.1111/j.1365-2273.1994.tb01190.x.

Abstract

Blunt head injury frequently results in visual impairment, the optimal treatment of which is still debated. Over a 5-year-period (1987-1991) 111 patients with indirect optic nerve injury resulting from closed head trauma have been treated. In each case loss of vision was the only neurological deficit. In group A, 66 patients were initially treated with large doses of prednisolone (80 mg/day) for 3 weeks. Twenty-seven patients improved on steroids alone. In the remaining 39 patients in whom either unsatisfactory or no improvement occurred a transethmoidal optic nerve decompression was performed. Twenty-two patients in the latter group improved, thus yielding an overall improvement rate of 74.2% in group A. Group B (control), in which 45 patients were treated with prednisolone only (80 mg/day for 3 weeks), had an overall improvement rate of 51% (23 patients). The study reveals that while nearly half of such patients can improve on steroids alone, optic nerve decompression significantly improves recovery rates in patients where conservative treatment is unsatisfactory (P < 0.05). Total loss of vision not responding to steroids, absence of waveform on visual evoked response, and presence of an optic canal fracture indicate a poor prognosis.

摘要

钝性头部损伤常导致视力障碍,其最佳治疗方法仍存在争议。在1987年至1991年的5年期间,对111例因闭合性头部创伤导致间接视神经损伤的患者进行了治疗。每例患者视力丧失均为唯一的神经功能缺损。A组66例患者最初接受大剂量泼尼松龙(80mg/天)治疗3周。仅使用类固醇治疗的患者中有27例病情好转。在其余39例治疗效果不佳或无改善的患者中,进行了经筛窦视神经减压术。后一组中有22例患者病情好转,因此A组的总体改善率为74.2%。B组(对照组)45例患者仅接受泼尼松龙治疗(80mg/天,共3周),总体改善率为51%(23例患者)。该研究表明,虽然近一半的此类患者仅使用类固醇治疗即可改善病情,但视神经减压术可显著提高保守治疗效果不佳患者的恢复率(P<0.05)。对类固醇治疗无反应的完全视力丧失、视觉诱发电位无波形以及存在视神经管骨折均提示预后不良。

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