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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zarrindast M R, Rezayat M

Department of Pharmacology, School of Medicine, University of Tehran, Iran.

Gen Pharmacol. 1994 Mar;25(2):311-6. doi: 10.1016/0306-3623(94)90060-4.

In the present study, the effect of caerulein (CLN) on morphine analgesia has been tested. 2. Different doses of morphine produced antinociception in a dose dependent manner. When animals were pretreated with CLN 5 min before morphine administration, the morphine response was decreased. However, when CLN was injected 30 or 60 min prior to morphine, the drug effect was increased. 3. Naloxone, sulpiride, metergoline or proglumide decreased the potentiation of morphine response caused by CLN. CLN, proglumide, sulpiride, metergoline and naloxone alone did not exert any effect on tail-flick latency. 4. It is concluded that, depending on pretreatment times of CLN administration the response of morphine was decreased or increased and D-2 dopamine, serotonin and/or CCK receptors may be involved in the potentiation of morphine response induced by CLN.

在本研究中，已测试了雨蛙肽（CLN）对吗啡镇痛作用的影响。2. 不同剂量的吗啡以剂量依赖方式产生抗伤害感受作用。当在给予吗啡前5分钟用CLN预处理动物时，吗啡反应降低。然而，当在吗啡前30或60分钟注射CLN时，药物作用增强。3. 纳洛酮、舒必利、美替拉酮或丙谷胺降低了由CLN引起的吗啡反应增强作用。单独使用CLN、丙谷胺、舒必利、美替拉酮和纳洛酮对甩尾潜伏期没有任何影响。4. 得出的结论是，根据CLN给药的预处理时间不同，吗啡反应会降低或增强，并且D-2多巴胺、5-羟色胺和/或胆囊收缩素受体可能参与了CLN诱导的吗啡反应增强作用。

Zarrindast M R, Rezayat M

Department of Pharmacology, School of Medicine, University of Tehran, Iran.

Gen Pharmacol. 1994 Mar;25(2):311-6. doi: 10.1016/0306-3623(94)90060-4.

In the present study, the effect of caerulein (CLN) on morphine analgesia has been tested. 2. Different doses of morphine produced antinociception in a dose dependent manner. When animals were pretreated with CLN 5 min before morphine administration, the morphine response was decreased. However, when CLN was injected 30 or 60 min prior to morphine, the drug effect was increased. 3. Naloxone, sulpiride, metergoline or proglumide decreased the potentiation of morphine response caused by CLN. CLN, proglumide, sulpiride, metergoline and naloxone alone did not exert any effect on tail-flick latency. 4. It is concluded that, depending on pretreatment times of CLN administration the response of morphine was decreased or increased and D-2 dopamine, serotonin and/or CCK receptors may be involved in the potentiation of morphine response induced by CLN.

在本研究中，已测试了雨蛙肽（CLN）对吗啡镇痛作用的影响。2. 不同剂量的吗啡以剂量依赖方式产生抗伤害感受作用。当在给予吗啡前5分钟用CLN预处理动物时，吗啡反应降低。然而，当在吗啡前30或60分钟注射CLN时，药物作用增强。3. 纳洛酮、舒必利、美替拉酮或丙谷胺降低了由CLN引起的吗啡反应增强作用。单独使用CLN、丙谷胺、舒必利、美替拉酮和纳洛酮对甩尾潜伏期没有任何影响。4. 得出的结论是，根据CLN给药的预处理时间不同，吗啡反应会降低或增强，并且D-2多巴胺、5-羟色胺和/或胆囊收缩素受体可能参与了CLN诱导的吗啡反应增强作用。