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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Aricioğlu A, Aydin S, Turkozkan N, Durmus O

Department of Biochemistry, Medical Faculty, Gazi University, Ankara, Turkey.

Gen Pharmacol. 1994 Mar;25(2):341-4. doi: 10.1016/0306-3623(94)90064-7.

Na+K+ATPase is a membrane bound enzyme whose activity is essential for maintenance of cell viability. Lipid peroxidation changes membrane fluidity and enzyme activity. 2. The purpose of this study was to investigate the effect of allopurinol (free radical scavenger) on Na+K+ATPase activity in rabbit kidney cortex membrane. In this in vivo study we created ischemia and reperfusion in rabbit kidneys. 3. Enzyme activity were low in ischemic and reperfused kidneys, compared to the controls. In allopurinol treated ischemic and reperfused groups, the levels of Na+K+ATPase activity were high compared to the untreated group. 4. It has been concluded that allopurinol may protect this enzyme activity.

钠钾ATP酶是一种膜结合酶，其活性对于维持细胞活力至关重要。脂质过氧化会改变膜流动性和酶活性。2. 本研究的目的是探讨别嘌醇（自由基清除剂）对兔肾皮质膜中钠钾ATP酶活性的影响。在这项体内研究中，我们在兔肾中制造了缺血和再灌注。3. 与对照组相比，缺血和再灌注肾脏中的酶活性较低。在别嘌醇处理的缺血和再灌注组中，钠钾ATP酶活性水平高于未处理组。4. 得出的结论是，别嘌醇可能会保护这种酶的活性。

Aricioğlu A, Aydin S, Turkozkan N, Durmus O

Department of Biochemistry, Medical Faculty, Gazi University, Ankara, Turkey.

Gen Pharmacol. 1994 Mar;25(2):341-4. doi: 10.1016/0306-3623(94)90064-7.

Na+K+ATPase is a membrane bound enzyme whose activity is essential for maintenance of cell viability. Lipid peroxidation changes membrane fluidity and enzyme activity. 2. The purpose of this study was to investigate the effect of allopurinol (free radical scavenger) on Na+K+ATPase activity in rabbit kidney cortex membrane. In this in vivo study we created ischemia and reperfusion in rabbit kidneys. 3. Enzyme activity were low in ischemic and reperfused kidneys, compared to the controls. In allopurinol treated ischemic and reperfused groups, the levels of Na+K+ATPase activity were high compared to the untreated group. 4. It has been concluded that allopurinol may protect this enzyme activity.

钠钾ATP酶是一种膜结合酶，其活性对于维持细胞活力至关重要。脂质过氧化会改变膜流动性和酶活性。2. 本研究的目的是探讨别嘌醇（自由基清除剂）对兔肾皮质膜中钠钾ATP酶活性的影响。在这项体内研究中，我们在兔肾中制造了缺血和再灌注。3. 与对照组相比，缺血和再灌注肾脏中的酶活性较低。在别嘌醇处理的缺血和再灌注组中，钠钾ATP酶活性水平高于未处理组。4. 得出的结论是，别嘌醇可能会保护这种酶的活性。