曼氏血吸虫（扁形虫）中的二核苷酸偏好性

Dinucleotide biases in the platyhelminth Schistosoma mansoni.

作者信息

Musto H, Alvarez F, Tort J, Maseda H R

机构信息

Sección Bioquímica, Facultad de Ciencias, Montevideo, Uruguay.

出版信息

Int J Parasitol. 1994 Apr;24(2):277-83. doi: 10.1016/0020-7519(94)90039-6.

DOI:10.1016/0020-7519(94)90039-6

PMID:8026908

Abstract

The analysis of dinucleotide biases in coding and flanking regions, introns, rDNA and repetitive sequences, in the flatworm Schistosoma mansoni is reported. Except for rDNA, all regions display CpG avoidance and TpG plus CpA excess, which might be evidence of the presence of 5mC. The distribution and hierarchies of dinucleotides differ from the data published for invertebrate and vertebrate coding sequences.

摘要

本文报道了对曼氏血吸虫编码区、侧翼区、内含子、核糖体DNA（rDNA）和重复序列中二核苷酸偏好性的分析。除rDNA外，所有区域均表现出对CpG的规避以及TpG和CpA的过量，这可能是5-甲基胞嘧啶（5mC）存在的证据。二核苷酸的分布和层次结构与已发表的无脊椎动物和脊椎动物编码序列的数据不同。