Mullaji A B, Upadhyay S S, Ho E K
Duchess of Kent Children's Hospital, Hong Kong.
J Bone Joint Surg Br. 1994 Jul;76(4):660-5.
We have used dual-energy X-ray absorptiometry to measure bone mineral density (BMD) in patients with ankylosing spondylitis comparing 41 healthy control subjects and 33 patients with either mild or advanced ankylosing spondylitis. A Norland XR-28 bone densitometer was used to measure the BMD of the lumbar spine and that of the head, trunk, arms, femoral neck, Ward's triangle, legs, pelvis, and total body. Mild ankylosing spondylitis was defined as that showing no or incipient syndesmophytes between L1 and L5 vertebrae: we studied 16 men of mean age 37 years and six women of mean age 37 years. Advanced ankylosing spondylitis, in 11 men of mean age 42 years, showed a bamboo spine with bridging syndesmophytes across all disc spaces between L1 and L5. The mean BMD of the lumbar spine was significantly different in the patients and control subjects of the same sex (0.01 < p < 0.05, analysis of variance), being significantly reduced compared with control subjects in mild disease (0.001 < p < 0.01, t-test) and significantly increased in advanced disease over control subjects (0.01 < p < 0.05; t-test) and over patients with mild disease (0.001 < p < 0.01; t-test). The relevance of these findings to the aetiology and pathogenesis of spinal deformities and other complications in ankylosing spondylitis is discussed.
我们使用双能X线吸收法测量了强直性脊柱炎患者的骨密度（BMD），并与41名健康对照者以及33名患有轻度或重度强直性脊柱炎的患者进行了比较。使用Norland XR - 28骨密度仪测量腰椎、头部、躯干、手臂、股骨颈、沃德三角区、腿部、骨盆和全身的骨密度。轻度强直性脊柱炎定义为L1至L5椎体之间无或仅有初期骨桥形成：我们研究了16名平均年龄37岁的男性和6名平均年龄37岁的女性。重度强直性脊柱炎患者有11名，平均年龄42岁，表现为竹节样脊柱，L1至L5所有椎间盘间隙均有骨桥形成。相同性别的患者和对照者腰椎的平均骨密度存在显著差异（方差分析，0.01 < p < 0.05），与对照组相比，轻度疾病患者的骨密度显著降低（t检验，0.001 < p < 0.01），重度疾病患者的骨密度显著高于对照组（t检验，0.01 < p < 0.05）且高于轻度疾病患者（t检验，0.001 < p < 0.01）。本文讨论了这些发现与强直性脊柱炎脊柱畸形及其他并发症的病因和发病机制的相关性。
