一名因抗胰岛素受体抗体导致慢性严重胰岛素抵抗患者的胰岛淀粉样变。
Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies.
作者信息
O'Brien T D, Rizza R A, Carney J A, Butler P C
机构信息
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
出版信息
J Clin Endocrinol Metab. 1994 Jul;79(1):290-2. doi: 10.1210/jcem.79.1.8027243.
PMID:8027243
Abstract
We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic beta-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.
摘要
我们报告了一例因循环抗胰岛素受体抗体导致严重胰岛素抵抗的病例，其中存在胰岛增生、胰岛细胞增殖症和大量胰岛淀粉样变（源自胰岛淀粉样多肽）。大量慢性β细胞刺激（以及非胰岛素依赖型糖尿病和胰岛素瘤）似乎与胰岛淀粉样变有关。
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