Poulin S A, Perkins R E, Kundsin R B
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
J Clin Microbiol. 1994 Apr;32(4):1101-3. doi: 10.1128/jcm.32.4.1101-1103.1994.
Because mycoplasmas may be a cofactor in the progression of human immunodeficiency virus infection to AIDS, their susceptibilities to antibiotics need to be known in the event that appropriate therapy is required. The mycoplasmas studied were a stock culture strain of Mycoplasma fermentans, two strains of M. fermentans isolated from patients with AIDS, M. fermentans var. incognitus, Mycoplasma penetrans, and Mycoplasma pirum. The antibiotics tested were doxycycline, tetracycline, clindamycin, ofloxacin, erythromycin, azithromycin, and clarithromycin at levels consistent with the attainable levels in serum. By the macrodilution metabolic inhibition method, all six mycoplasma strains were susceptible to doxycycline, tetracycline, clindamycin, ofloxacin, azithromycin, and clarithromycin. M. penetrans was susceptible to erythromycin. The M. fermentans strains and M. pirum were resistant to erythromycin. The macrodilution metabolic inhibition method results showed agreement with the Sensititre Gram Positive MIC Panel results for tetracycline, clindamycin, and erythromycin. MICs of clarithromycin for all six mycoplasma isolates tested were low, indicating susceptibility.
由于支原体可能是人类免疫缺陷病毒感染进展为艾滋病的一个辅助因素，若需要进行适当治疗，就需要了解它们对抗生素的敏感性。所研究的支原体包括发酵支原体的一个标准培养菌株、从艾滋病患者中分离出的两株发酵支原体、发酵支原体隐匿变种、穿透支原体和梨支原体。所测试的抗生素为多西环素、四环素、克林霉素、氧氟沙星、红霉素、阿奇霉素和克拉霉素，其浓度与血清中可达到的水平一致。通过微量稀释代谢抑制法，所有六种支原体菌株对多西环素、四环素、克林霉素、氧氟沙星、阿奇霉素和克拉霉素敏感。穿透支原体对红霉素敏感。发酵支原体菌株和梨支原体对红霉素耐药。微量稀释代谢抑制法的结果与Sensititre革兰氏阳性菌MIC检测板对四环素、克林霉素和红霉素的检测结果一致。所测试的所有六种支原体分离株对克拉霉素的MIC均较低，表明它们敏感。
