Hall A G, McGuckin A G, Pearson A D, Cattan A R, Malcolm A J, Reid M M
Leukaemia Research Fund Remission Unit, Medical School, Newcastle upon Tyne.
J Clin Pathol. 1994 May;47(5):468-9. doi: 10.1136/jcp.47.5.468.
Antisera to each of the three main cytosolic forms of glutathione S-transferase (GST; alpha, mu, and pi) has been used to characterise GST expression by metastatic neuroblastoma in bone marrow trephine biopsies taken from 15 patients at presentation and from five of this group at relapse. There was no correlation between expression of extra-nuclear alpha or mu GST and outcome, and no consistent pattern at relapse. Seven of eight expressing nuclear pi GST at presentation died of resistant disease. Three of five cases with no detectable nuclear pi class GST remain alive and disease free. The results provide no encouragement for further investigation of alpha or mu GST in this disease but larger studies of uniformly treated patients may show whether nuclear pi GST expression at presentation indicates likely relapse.
针对谷胱甘肽S-转移酶（GST；α、μ和π）三种主要胞质形式的抗血清，已用于对15例初诊患者及其中5例复发患者的骨髓环钻活检中转移性神经母细胞瘤的GST表达进行表征。核外α或μ GST的表达与预后之间无相关性，复发时也无一致模式。初诊时表达核π GST的8例患者中有7例死于耐药性疾病。5例未检测到核π类GST的患者中有3例仍存活且无疾病。这些结果不支持对该疾病中的α或μ GST进行进一步研究，但对接受统一治疗的患者进行更大规模的研究可能会表明初诊时核π GST的表达是否预示可能复发。
