苯甲酸和3-甲氧基苯甲酸酰肼的铂（II）配合物。合成、表征及细胞毒性作用。
Platinum (II) complexes of benzoic- and 3-methoxybenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect.
作者信息
Dodoff N, Grancharov K, Gugova R, Spassovska N
机构信息
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
出版信息
J Inorg Biochem. 1994 May 15;54(3):221-33. doi: 10.1016/0162-0134(94)80015-4.
The complexes [Pt(bah)2X2], [Pt(NH3)(bah)Cl2].0.5H2O, [Pt(mbah)2X2], and [Pt(NH3)(mbah)Cl2] (bah = benzoic acid hydrazide, mbah = 3-methoxybenzoic acid hydrazide; X = Cl, Br, I) have been prepared and characterized by elemental analysis, electric conductivity, IR, 1H NMR, and electronic spectra. A cis-square planar structure with hydrazide ligands coordinated via the NH2-groups has been proposed for these complexes. The complexes have shown a growth-inhibitory effect against Friend leukemia cells in culture comparable to that of the antitumor drug cisplatin.
已制备出配合物[Pt(bah)₂X₂]、[Pt(NH₃)(bah)Cl₂]·0.5H₂O、[Pt(mbah)₂X₂]和[Pt(NH₃)(mbah)Cl₂]（bah = 苯甲酸酰肼，mbah = 3 - 甲氧基苯甲酸酰肼；X = Cl、Br、I），并通过元素分析、电导率、红外光谱、¹H核磁共振谱和电子光谱对其进行了表征。已针对这些配合物提出了一种顺式 - 平面正方形结构，其中酰肼配体通过NH₂基团配位。这些配合物在培养中对弗瑞德白血病细胞显示出与抗肿瘤药物顺铂相当的生长抑制作用。
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