Godai K, Daito K, Yamada S, Uemasu J, Horie Y, Suou T, Kawasaki H
Second Department of Internal Medicine, Tottori University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1994 Jun;91(6):1097-103.
To elucidate the immunological effects of transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC), serum and urinary neopterins were measured using the radioimmunoassay in patients with HCC before and after TAE (n = 11), and compared with one shot arterial injection (AI)(n = 8). At the third day after TAE, serum and urinary neopterin levels were maximally elevated up to 164% and 158% from their respective baselines (p < 0.01). By contrast, these levels were unaffected after AI. In considering the changes of natural killer cell activity, C-reactive protein, transaminase and alpha-fetoprotein, these results suggest that the determination of neopterin levels after TAE may be not only valuable to assess the necrotic effect of TAE, but also be useful for evaluating cellular immunity after TAE.
为阐明经导管动脉栓塞术（TAE）治疗肝细胞癌（HCC）的免疫效应，采用放射免疫分析法对11例接受TAE治疗的HCC患者TAE术前及术后的血清和尿新蝶呤进行测定，并与8例单次动脉注射（AI）患者进行比较。TAE术后第3天，血清和尿新蝶呤水平分别较各自基线水平最大升高164%和158%（p<0.01）。相比之下，AI术后这些水平未受影响。综合自然杀伤细胞活性、C反应蛋白、转氨酶和甲胎蛋白的变化情况，这些结果表明，TAE术后测定新蝶呤水平不仅有助于评估TAE的坏死效果，还可用于评价TAE后的细胞免疫。
