Sprott R L, Stavnes K
Exp Aging Res. 1975 Sep;1(1):145-68. doi: 10.1080/03610737508257956.
Animal models of human aging problems are potentially of enormous value to gerontological research. Models of behavioral problems have not often lived up to their promise. This review examines one such model system, avoidance learning in aging rodents. This model system has become increasingly popular among behavioral gerontologists, yet it has not provided the unambiguous answers to experimental questions which investigators expected. Our effort has been to determine why the system has failed, and to provide useful suggestions for future research. At the same time we have tried to provide a comprehensive review of the relevant literature and to assess the strengths and weaknesses of studies which have been conducted in the last two decades.
人类衰老问题的动物模型对老年学研究可能具有巨大价值。行为问题模型往往未能兑现其承诺。本综述考察了这样一个模型系统，即衰老啮齿动物的回避学习。这个模型系统在行为老年学家中越来越受欢迎，但它并未为研究人员期望的实验问题提供明确答案。我们的努力在于确定该系统失败的原因，并为未来研究提供有用建议。同时，我们试图对相关文献进行全面综述，并评估过去二十年中所开展研究的优缺点。
