Parramón M, Oset-Gasque M J, Gonzalez M P, Stephenson F A
Instituto de Bioquímica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Neurosci Lett. 1994 Feb 28;168(1-2):243-6. doi: 10.1016/0304-3940(94)90460-x.
The GABAA receptor subunits expressed in adrenal medulla have been characterized by radioligand binding and by immunological methods. The receptors were purified by both benzodiazepine affinity chromatography and anti-alpha 1 413-429 GABAA receptor antibody immunoaffinity chromatography. These preparations were screened by immunoblotting using GABA receptor alpha subunit sequence-specific antibodies. Results showed the existence of the alpha 1 subunit. Thus, the GABAA receptors expressed in adrenal medulla are homogeneous with respect to their alpha subunit complement and consistent with type BZ1 benzodiazepine receptor pharmacology.
