Elden L, Montanera W, Terbrugge K, Willinsky R, Lasjaunias P, Charles D
Ear, Nose, and Throat Department, University of Toronto, Ontario, Canada.
Otolaryngol Head Neck Surg. 1994 Jul;111(1):44-50. doi: 10.1177/019459989411100110.
Ninety-seven patients were referred to the Toronto Hospital (Western Division) between January 1984 and January 1992 for selective angiographic embolization (108 embolizations, including repeat procedures) to control intractable or recurrent severe epistaxis. Eighty-one patients (comprising 94 embolizations) were referred on an emergent basis because of failure of conventional conservative therapy, consisting of anterior and posterior packing. The remaining 16 patients (14 embolizations) were referred electively for recurrent epistaxis. A retrospective review of these cases was performed, with long-term telephone follow-up achieved in over 95% of cases. Embolization safely controlled active hemorrhage in 88% of the emergent cases. The success rate increased to 90% when two cases in which the source of epistaxis was found to be from the internal carotid artery were excluded (because these vessels could not be safely embolized). Of the patients whose epistaxis was initially controlled by embolization, 82% had no further nosebleeds (follow-up time ranged from 2 to 82 months; average, 26.8 months). More than half of the long-term failures were seen in patients with Osler-Weber-Rendu disease. Overall, the mortality rate was 0% and the long-term morbidity rate was 2% (one cerebral vascular accident and one case of skin slough in the territory of the superficial temporal artery.
1984年1月至1992年1月期间,97例患者被转诊至多伦多医院(西区)接受选择性血管造影栓塞术(共108次栓塞,包括重复操作),以控制难治性或复发性严重鼻出血。81例患者(共94次栓塞)因传统保守治疗(包括前后鼻孔填塞)失败而被紧急转诊。其余16例患者(14次栓塞)因复发性鼻出血而被选择性转诊。对这些病例进行了回顾性研究,超过95%的病例通过电话进行了长期随访。栓塞术在88%的紧急病例中安全地控制了活动性出血。若排除2例鼻出血源为颈内动脉的病例(因为这些血管无法安全栓塞),成功率可提高至90%。在鼻出血最初通过栓塞术得到控制的患者中,82%未再发生鼻出血(随访时间为2至82个月;平均26.8个月)。超过半数的长期治疗失败病例见于遗传性出血性毛细血管扩张症患者。总体而言,死亡率为0%,长期发病率为2%(1例脑血管意外和1例颞浅动脉供血区域皮肤坏死)。