Gohbara H
Department of Radiology, Okayama University Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1994 May 25;54(6):510-9.
99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) is a new liver imaging agent which binds to heptic binding protein. This study evaluated the sensitivity of 99mTc-GSA kinetics and imaging anatomy to congestive hepatic injury in rats. Regional hepatic congestion was induced by clamping the left hepatic vein for 5, 10, 20, 40, or 90 min. After recanalization, 99mTc-GSA was intravenously administered to rats. A dynamic imaging study was performed, followed by static liver imaging performed for 5 min. A hepatic accumulation index, t90, was obtained on the basis of the dynamic data. A significant difference in t90 was observed between the experimental groups and the controls (p < 0.01). A significant difference in s-GPT also was observed between the experimental groups and the controls (p < 0.01). Excellent correlations were seen between t90 and ligation time (r = 0.967, p < 0.001), and t90 and s-GPT (r = 0.907, p < 0.001). Marked depression in hepatic 99mTc-GSA uptake was observed in rats with 40 or 90 min of hepatic vein occlusion. In conclusion, 99mTc-GSA is useful for evaluating hepatic injury in rats induced by hepatic vein occlusion.
99m锝-二乙三胺五乙酸-半乳糖基人血清白蛋白（99mTc-GSA）是一种新型肝脏显像剂，可与肝脏结合蛋白结合。本研究评估了99mTc-GSA动力学及成像解剖对大鼠充血性肝损伤的敏感性。通过夹闭大鼠左肝静脉5、10、20、40或90分钟诱导局部肝充血。再通后，给大鼠静脉注射99mTc-GSA。进行动态显像研究，随后进行5分钟的肝脏静态显像。根据动态数据获得肝脏摄取指数t90。实验组与对照组之间t90存在显著差异（p<0.01）。实验组与对照组之间血清谷丙转氨酶（s-GPT）也存在显著差异（p<0.01）。t90与结扎时间之间（r=0.967，p<0.001）以及t90与s-GPT之间（r=0.907，p<0.001）均呈现出良好的相关性。在肝静脉闭塞40或90分钟的大鼠中观察到肝脏对99mTc-GSA摄取明显降低。总之，99mTc-GSA可用于评估大鼠肝静脉闭塞所致的肝损伤。
