Bacia T, Bendarzewska-Nawrocka B, Urbaniak J W
Pracowni Elektroencefalografii i Neurofizjologii Klinicznej Kliniki Neurochirurgii AM, Warszawie.
Pol Tyg Lek. 1994;49(4-5):115-7.
Monotherapy with one drug chosen out of basic anti-epileptic agents was carried out in 312 patients, including 2/3 of cases resistant to the drugs. Group A consisted of 110 patients treated with a single drug since the onset of the disease whereas group B consisted of 202 patients in whom polytherapy was reduced to monotherapy. The best results were achieved in patients of group A with short and medium duration of the disease. The results noted in patients of group B were worse and independent of the duration of epilepsy. The most favourable effects were noted in children with mild epilepsy and generalized epilepsy of unknown post-traumatic etiology. The results of monotherapy in focal seizures and epilepsy with organic lesions were markedly worse. The most effective drugs in this population were: barbiturates, valproic acid derivatives, and carbamazepine. The authors stress that all forms of epilepsy, especially newly diagnosed and previously untreated cases, should be treated with single agent.
对312例患者采用从基本抗癫痫药物中选择的一种药物进行单药治疗，其中包括2/3对药物耐药的病例。A组由110例自疾病发作起就接受单一药物治疗的患者组成，而B组由202例从多药治疗减为单药治疗的患者组成。病程短和中等的A组患者取得了最佳疗效。B组患者的治疗结果较差，且与癫痫病程无关。在患有轻度癫痫和创伤后病因不明的全身性癫痫的儿童中观察到最有利的效果。局灶性癫痫和伴有器质性病变的癫痫的单药治疗结果明显较差。该人群中最有效的药物是：巴比妥类、丙戊酸衍生物和卡马西平。作者强调，所有形式的癫痫，尤其是新诊断和以前未治疗的病例，都应以单一药物进行治疗。
