Szepietowski T, el-Hayek A
Katedra i Klinika Nefrologii AM, Wrocławiu.
Polim Med. 1993;23(3-4):43-54.
In 14 patients beta 2-microglobulin serum concentration before and after haemodialysis using cuprophane capillary dialyzers with 0.7; 1.2 and 1.5 m2 surface was measured. beta 2-microglobulin concentration did not change during the haemodialysis procedure using 0.7 m2 dialyzers and was 31.15 +/- 7.58 mg/l before the dialysis and 31.10 +/- 13.59 mg/l after the procedure. Using 1.2 m2 dialyzers beta 2-microglobulin serum level increased (not significantly) from 29.40 +/- 7.53 mg/l before dialysis up to 36.29 +/- 11.70 mg/l after dialysis. When employed 1.5 m2 dialyzers the increase of beta 2-microglobulin serum concentration was higher and statistically significant (p < 0.02). The values of beta 2-microglobulin serum level before and after the haemodialysis were 29.89 +/- 2.44 mg/l and 38.04 +/- 5.89 mg/l respectively. There was a significant increase of number of patients with higher beta 2-microglobulin serum level (p < 0.01) according to the increase of dialyzers surface. beta 2-microglobulin concentration after the haemodialysis procedure using 0.7 m2 dialyzers was lower than calculation of protein changes could show. However using 1.2 and 1.5 m2 dialyzers beta 2-microglobulin serum level was markedly higher (statistically significant (p < 0.05) when employed 1.5 m2 dialyzers), than expected using the some above calculation. The increase of beta 2-microglobulin showed positive, but statistically not significant correlation with the index of haemodialysis intensitivity. The above mentioned data indicate that the increase of beta 2-microglobulin after haemodialysis is not related to biocompatibility of cuprophane membrane, but is dependent on intensivity of haemodialysis, which associated with the surface of the membrane.
对14例患者使用表面积分别为0.7平方米、1.2平方米和1.5平方米的铜仿膜毛细管透析器进行血液透析前后的β2 -微球蛋白血清浓度进行了测量。使用0.7平方米透析器进行血液透析过程中，β2 -微球蛋白浓度未发生变化，透析前为31.15±7.58毫克/升，透析后为31.10±13.59毫克/升。使用1.2平方米透析器时，β2 -微球蛋白血清水平从透析前的29.40±7.53毫克/升（无显著升高）升至透析后的36.29±11.70毫克/升。使用1.5平方米透析器时，β2 -微球蛋白血清浓度升高幅度更大且具有统计学意义（p<0.02）。血液透析前后β2 -微球蛋白血清水平分别为29.89±2.44毫克/升和38.04±5.89毫克/升。随着透析器表面积的增加，β2 -微球蛋白血清水平较高的患者数量显著增加（p<0.01）。使用0.7平方米透析器进行血液透析后，β2 -微球蛋白浓度低于根据蛋白质变化计算得出的结果。然而，使用1.2平方米和1.5平方米透析器时，β2 -微球蛋白血清水平明显更高（使用1.5平方米透析器时具有统计学意义（p<0.05）），高于上述计算预期。β2 -微球蛋白的升高与血液透析强度指数呈正相关，但无统计学意义。上述数据表明，血液透析后β2 -微球蛋白的升高与铜仿膜的生物相容性无关，而是取决于与膜表面积相关的血液透析强度。
