Nikitinskaia L P, Stetsiuk E A, Iarmolinskiĭ I S, Barinov A V, Kon'kova T A
Urol Nefrol (Mosk). 1990 Sep-Oct(5):29-31.
The authors studied changes of the beta 2-microglobulin level during hemodialysis with dialyzers AIP-02-02 (cuprophane membrane), E2 (cuprophane membrane), AIP-03-02 (polysulfone membrane), F60 (polysulfone membrane), and hemodiafiltration with dialyzer F60. The following data were obtained. The beta 2-microglobulin level in patients undergoing hemodialysis is approximately 20 times the normal level. No essential fluctuations of the level of this protein occurs during hemodialysis and hemodiafiltration. The cuprophane membrane does not cause increase of beta 2-microglobulin generation during hemodialysis. Standard hemodialysis with the cuprophane membrane and the highly-permeable polysulfone membrane does not lead to decrease of the beta 2-microglobulin level. Hemodiafiltration with the highly-permeable polysulfone membrane is an effective method for the elimination of this protein.
作者研究了使用AIP - 02 - 02透析器（铜仿膜）、E2透析器（铜仿膜）、AIP - 03 - 02透析器（聚砜膜）、F60透析器（聚砜膜）进行血液透析期间以及使用F60透析器进行血液透析滤过期间β2 -微球蛋白水平的变化。获得了以下数据。接受血液透析的患者体内β2 -微球蛋白水平约为正常水平的20倍。在血液透析和血液透析滤过期间，该蛋白水平无明显波动。铜仿膜在血液透析期间不会导致β2 -微球蛋白生成增加。使用铜仿膜和高通透性聚砜膜进行的标准血液透析不会导致β2 -微球蛋白水平降低。使用高通透性聚砜膜进行血液透析滤过是清除该蛋白的有效方法。
