Zelder O
Chirurgischen Universitätsklinik, Marburg/Lahn.
Z Gastroenterol. 1976 Apr;14(2):298-308.
Special problems of liver transplantation were discussed on results and experiences in clinical and experimental transplantation during the last two decades. Heterotopic auxiliary transplantation in animals especially in rats by means of microsurgical techniques were pointed out. Although more than 200 orthotopic transplantations had been carried out, this procedure is still in clinical trial. Heterotopic auxiliary liver transplantation had been done almost exclusively in research with disappointing results in the early phase and different results later on. In the last years the indication for orthotopic liver transplantation was reduced to benign liver diseases with severe follow-up, originally a field for heterotopic auxiliary transplantation. In future many problems, e.g. on preservation and blood supply, regeneration and rejection or biochemical function of liver grafts must be studied in clinic and research.
根据过去二十年临床和实验性肝移植的结果与经验，对肝移植的特殊问题进行了讨论。指出了通过显微外科技术在动物尤其是大鼠身上进行异位辅助肝移植。尽管已经进行了200多例原位肝移植，但该手术仍处于临床试验阶段。异位辅助肝移植几乎仅用于研究，早期结果令人失望，后来结果有所不同。在过去几年中，原位肝移植的适应症已缩小到伴有严重后续问题的良性肝病，而这原本是异位辅助肝移植的领域。未来，许多问题，如肝脏移植的保存和血液供应、再生与排斥反应或生化功能等，都必须在临床和研究中进行探讨。
