Pulvirenti L, Koob G F
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Pharmacol Biochem Behav. 1994 Apr;47(4):819-22. doi: 10.1016/0091-3057(94)90281-x.
The maintenance of intravenous (i.v.) cocaine self-administration appears to depend upon activation of dopamine terminals within mesocorticolimbic areas. Since the nonaddictive ergot derivative lisuride is a direct dopamine receptor agonist, the present study was designed to investigate whether administration of lisuride to rats trained to lever-press for IV self-administration of cocaine could affect the intake of cocaine. IP administration of several doses of lisuride reduced, in a dose-dependent manner, cocaine self-administration. In a control experiment, lisuride did not increase the psychomotor-activating properties of cocaine as measured by locomotor activity, suggesting that lisuride did not simply potentiate the activating effects of cocaine. The present results show that lisuride reduced IV cocaine self-administration in rats; the possibility of a new therapeutic approach to the treatment of cocaine abuse in humans using lisuride may therefore deserve clinical attention.
静脉注射可卡因自我给药行为的维持似乎依赖于中脑皮质边缘区域内多巴胺能终末的激活。由于非成瘾性麦角衍生物利苏瑞得是一种直接的多巴胺受体激动剂，本研究旨在探讨对经训练通过杠杆按压进行静脉注射可卡因自我给药的大鼠给予利苏瑞得是否会影响可卡因的摄入量。腹腔注射几种剂量的利苏瑞得可剂量依赖性地减少可卡因自我给药行为。在一项对照实验中，利苏瑞得并未如通过自发活动所测量的那样增强可卡因的精神运动激活特性，这表明利苏瑞得并非简单地增强可卡因的激活作用。目前的结果表明，利苏瑞得可减少大鼠静脉注射可卡因的自我给药行为；因此，使用利苏瑞得治疗人类可卡因滥用的新治疗方法的可能性值得临床关注。
