Lin J S, Chang W C, Lui S M
Department of Urology, National Cheng Kung University Medical College, Tainan, Taiwan, R.O.C.
Proc Natl Sci Counc Repub China B. 1994 Jan;18(1):12-6.
Penile hypercoagulability during erection may predispose to aging vascular changes and, eventually, arteriogenic impotence. The relationship of penile blood thromboxane B2 and 6-keto-prostaglandin F1 alpha in both psychogenically and arteriogenically impotent patients after intracavernosal treatment with papaverine plus phentolamine or prostaglandin E1 was evaluated. No significant change in penile blood thromboxane B2 was observed with treatment of these vasoactive drugs. On the other hand, penile blood 6-keto-prostaglandin F1 alpha was significantly increased with the injection of 30 mg of papaverine plus 0.5 mg of phentolamine, and of 20 micrograms prostaglandin E1. Furthermore, the prostacyclin-to-thromboxane A2 ratio for the patient who received papaverine plus phentolamine was significantly lower than that for the same individual receiving prostaglandin E1. Our preliminary findings suggest that penile blood prostacyclin may participate in the pathogenesis of arteriogenic impotence and priapism.
勃起过程中阴茎的高凝状态可能会导致血管老化改变，并最终引发动脉性阳痿。我们评估了在精神性和动脉性阳痿患者中，经海绵体内注射罂粟碱加酚妥拉明或前列腺素E1治疗后，阴茎血液中血栓素B2和6-酮-前列腺素F1α的关系。使用这些血管活性药物治疗后，未观察到阴茎血液中血栓素B2有显著变化。另一方面，注射30毫克罂粟碱加0.5毫克酚妥拉明以及20微克前列腺素E1后，阴茎血液中6-酮-前列腺素F1α显著增加。此外，接受罂粟碱加酚妥拉明治疗的患者，其前列环素与血栓素A2的比值显著低于接受前列腺素E1治疗的同一患者。我们的初步研究结果表明，阴茎血液中的前列环素可能参与动脉性阳痿和阴茎异常勃起的发病机制。
