Neumann D R, Esselstyn C B, MacIntyre W J, Chen E Q, Go R T, Kohse L M, Licata A A
Department of Nuclear Medicine, Cleveland Clinic Foundation, OH 44195-5074.
Radiology. 1994 Aug;192(2):509-12. doi: 10.1148/radiology.192.2.8029424.
To explore the feasibility of use of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) to localize abnormal parathyroid tissue.
Regional body FDG PET with attenuation correction was performed in 17 adult patients with primary hyperparathyroidism (HPT) prior to surgical neck exploration. The regional body FDG PET results were correlated with surgical and histopathologic findings.
Surgical neck exploration revealed 18 parathyroid adenomas in 16 patients and four hyperplastic parathyroid glands in one patient. Regional body FDG PET allowed correct localization of 17 of the 18 parathyroid adenomas (94% sensitivity) and two of the four hyperplastic parathyroid glands (50% sensitivity). Three false-positive FDG PET findings were encountered, including two follicular thyroid adenomas.
Regional body FDG PET is a promising procedure for preoperative localization of pathologic parathyroid tissue in patients with primary HPT.
探讨使用2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）定位异常甲状旁腺组织的可行性。
对17例成年原发性甲状旁腺功能亢进症（HPT）患者在颈部手术探查前进行了带衰减校正的全身FDG PET检查。将全身FDG PET检查结果与手术及组织病理学结果进行对比。
颈部手术探查发现16例患者有18个甲状旁腺腺瘤，1例患者有4个增生的甲状旁腺。全身FDG PET能够正确定位18个甲状旁腺腺瘤中的17个（敏感性为94%）以及4个增生甲状旁腺中的2个（敏感性为50%）。出现了3例假阳性FDG PET结果，包括2个甲状腺滤泡性腺瘤。
全身FDG PET是一种很有前景的方法，可用于原发性HPT患者术前病理性甲状旁腺组织的定位。
