Hardeman M R, Konijnenberg A, Sturk A, Reekers J A
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Radiology. 1994 Aug;192(2):563-6. doi: 10.1148/radiology.192.2.8029432.
To determine the effects of an ionic low-osmolar contrast medium (ioxaglate) and two nonionic low-osmolar contrast media (iohexol and iopamidol) on human platelet activation in vitro.
Flow cytometry analysis subsequent to reaction with fluorescence-labeled monoclonal antibodies was used to detect antigens that appear on the platelet surface on activation.
Ioxaglate did not activate platelets, but evidence of platelet activation by iohexol and iopamidol was found in blood from two and three healthy volunteers, respectively, of the six volunteers studied. In addition, ioxaglate inhibited the thrombin-induced in vitro activation of platelets, whereas iohexol and iopamidol did not.
These findings support a tendency toward a higher frequency of thromboembolic complications with nonionic low-osmolar contrast media, although clinical trials will be needed to confirm this possible trend.
确定一种离子型低渗造影剂（碘克沙醇）和两种非离子型低渗造影剂（碘海醇和碘帕醇）对体外人血小板活化的影响。
与荧光标记单克隆抗体反应后，采用流式细胞术分析来检测活化时出现在血小板表面的抗原。
碘克沙醇未激活血小板，但在所研究的6名健康志愿者中，分别在2名和3名志愿者的血液中发现了碘海醇和碘帕醇激活血小板的证据。此外，碘克沙醇抑制凝血酶诱导的体外血小板活化，而碘海醇和碘帕醇则无此作用。
这些发现支持了非离子型低渗造影剂导致血栓栓塞并发症发生率较高的趋势，尽管需要临床试验来证实这一可能趋势。
