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异时基因与秀丽隐杆线虫发育的时间控制

Heterochronic genes and the temporal control of C. elegans development.

作者信息

Ambros V, Moss E G

机构信息

Department of Biological Sciences, Dartmouth College, Hanover, NH 03755.

出版信息

Trends Genet. 1994 Apr;10(4):123-7. doi: 10.1016/0168-9525(94)90213-5.

DOI:10.1016/0168-9525(94)90213-5
PMID:8029828
Abstract

The heterochronic genes of Caenorhabditis elegans encode part of a regulatory system that controls the temporal component of cell fates in development. The genes have been characterized genetically and molecularly, and their study has so far revealed a genetic hierarchy that specifies sequences of developmental events, a novel RNA-mediated mechanism of gene regulation and a reprogramming phenomenon associated with arrested development.

摘要

秀丽隐杆线虫的异时性基因编码了一个调控系统的一部分，该系统控制发育过程中细胞命运的时间组成部分。这些基因已在遗传学和分子层面得到表征，迄今为止对它们的研究揭示了一个确定发育事件顺序的遗传层次结构、一种新型的RNA介导的基因调控机制以及一种与发育停滞相关的重编程现象。

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