[苄青霉素对环磷酰胺在小鼠体内的细胞毒性和代谢活性水平的影响]
[Influence of benzyl penicillin on cytotoxicity and level of metabolic activity of cyclophosphamide in mice].
作者信息
Pakulska W, Graczyk J
机构信息
Zakład Farmakodynamiki, Katedra Farmakologii, Akademia Medyczna, Lódź.
出版信息
Acta Pol Pharm. 1993;50(2-3):159-63.
PMID:8030423
Abstract
The influence of benzylpenicillin on cytotoxicity of cyclophosphamide (CF) against leukaemia L 1210 was studied. The level of CF metabolites in mouse serum was traced. The benzylpenicillin appeared to enhance cytotoxic activity of CF and leads to increase of active metabolites when CF applied in high doses (300 mg/kg).
摘要
研究了苄青霉素对环磷酰胺（CF）抗白血病L 1210细胞毒性的影响。追踪了小鼠血清中CF代谢产物的水平。当高剂量（300 mg/kg）应用CF时，苄青霉素似乎增强了CF的细胞毒性活性并导致活性代谢产物增加。
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